Leslie, W.S., Taylor, R., Harris, L. and Lean, M.E.J. (2017) Weight losses with low energy formula diets in obese patients with and without type 2 diabetes: Systematic review and meta-analysis. International Journal of Obesity, 41(1), pp. 96-101. (doi: 10.1038/ijo.2016.175) (PMID:27698345)
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Abstract
Aim: To provide a systematic review, of published data, to compare weight losses following very low calorie (<800 kcal per day VLCD) or low-energy liquid-formula (>800 kcal per day LELD) diets, in people with and without type 2 diabetes mellitus (T2DM). Methods: Systematic electronic searches of Medline (1946–2015) and Embase (1947–2015) to identify published studies using formula total diet replacement diets (VLCD/LELD). Random effects meta-analysis using weighted mean difference (WMD) in body weight between groups (with and without diabetes) as the summary estimate. Results: Final weight loss, in the five included studies, weighted for study sizes, (n=569, mean BMI=35.5–42.6 kg/m2), was not significantly different between participants with and without T2DM: −1.2 kg; 95% CI: −4.1 to 1.6 kg). Rates of weight loss were also similar in the two groups −0.6 kg per week (T2DM) and 0.5 kg per week (no diabetes), and for VLCD (lt;800 kcal per day) and LELD (>800 kcal per day). Conclusions: Weight losses with liquid-formula diets are very similar for VLCD and LELD and for obese subjects with or without T2DM. They can potentially achieve new weight loss/ maintenance targets of >15–20% for people with severe and medically complicated obesity.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Lean, Professor Michael and Harris, Dr Leanne and Leslie, Dr Wilma |
Authors: | Leslie, W.S., Taylor, R., Harris, L., and Lean, M.E.J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
Journal Name: | International Journal of Obesity |
Publisher: | Nature Publishing Group |
ISSN: | 0307-0565 |
ISSN (Online): | 1476-5497 |
Published Online: | 04 October 2016 |
Copyright Holders: | Copyright © 2017 Macmillan Publishers Limited, part of Springer Nature |
First Published: | First published in International Journal of Obesity 41(1): 96-101 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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