A lipidomic analysis of placenta in preeclampsia: evidence for lipid storage

Brown, S. H.J., Eather, S. R., Freeman, D. J. , Meyer, B. J. and Mitchell, T. W. (2016) A lipidomic analysis of placenta in preeclampsia: evidence for lipid storage. PLoS ONE, 11(9), e0163972. (doi: 10.1371/journal.pone.0163972) (PMID:27685997) (PMCID:PMC5042456)

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In preeclampsia, maternal insulin resistance leads to defective expansion of adipocytes, enhanced adipocyte lipolysis, up-regulation of very low density lipoprotein synthesis, maternal hypertriglyceridaemia and the potential for ectopic fat storage. Our aim was to quantitate and compare the total amount and type of lipid in placenta from pregnancies complicated with preeclampsia and healthy pregnancies. Quantitative lipid analysis of lipid extracts from full thickness placental biopsies was carried out by shotgun lipidomics. Placental lipid profiles from pregnancies complicated by preeclampsia (n = 23) were compared to healthy pregnancies (n = 68), and placenta from intrauterine growth restriction pregnancies (n = 10) were used to control for gross differences in placental pathology. Placentae from pregnancies complicated with preeclampsia had higher neutral lipid content than healthy placentae (40% higher triacyglycerol (P = 0.001) and 33% higher cholesteryl ester (P = 0.004)) that was specific to preeclampsia and independent of maternal gestation.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Meyer, Ms Barbara and Freeman, Dr Dilys
Authors: Brown, S. H.J., Eather, S. R., Freeman, D. J., Meyer, B. J., and Mitchell, T. W.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:PLoS ONE
Publisher:Public Library of Science
ISSN (Online):1932-6203
Published Online:29 September 2016
Copyright Holders:Copyright © 2016 Brown et al.
First Published:First published in PLoS ONE 11(9):e0163972
Publisher Policy:Reproduced under a creative commons license

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
345561Is there a link between inflammation and insulin resistance in pre-eclampsia?Vanessa RodieScottish Executive Health Department (SEHHD-CSO)CZG/1/74SM - FORENSIC MEDICINE
366741Adipocyte lipolysis as a candidate pathway in the pathogenesis of pre-eclampsiaNaveed SattarBritish Heart Foundation (BHF)PG/03/147/16351RI CARDIOVASCULAR & MEDICAL SCIENCES
341641Are microparticles related to the increased expression of cardiovascular risk factors acquired in pre-eclampsia?Dilys FreemanBritish Heart Foundation (BHF)PG/02/167/14801MVLS MED -HUMAN NUTRITION