Currie, G. and Delles, C. (2016) Urinary proteomics for diagnosis and monitoring of diabetic nephropathy. Current Diabetes Reports, 16(11), 104. (doi: 10.1007/s11892-016-0798-3) (PMID:27658932)
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Abstract
The last decade has seen a surge in publications describing novel biomarkers for early detection of diabetic nephropathy (DN), but as yet none have outperformed albuminuria in well-designed prospective studies. This is partially attributable to our incomplete understanding of the many complex interrelated mechanisms underlying DN development, a heterogeneous process unlikely to be captured by a single biomarker. Proteomics offers the advantage of simultaneously analysing the entire protein content of a biological sample, and the technique has gained attention as a potential tool for a more accurate diagnosis of disease at an earlier stage as well as a means by which to unravel the pathogenesis of complex diseases such as DN using an untargeted approach. This review will discuss the potential of proteomics as both a clinical and research tool, evaluating exploratory work in animal models as well as diagnostic potential in human subjects.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Delles, Professor Christian and Currie, Dr Gemma |
| Authors: | Currie, G., and Delles, C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Current Diabetes Reports |
| Publisher: | Springer |
| ISSN: | 1534-4827 |
| ISSN (Online): | 1539-0829 |
| Published Online: | 23 September 2016 |
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