Zoltner, M., Horn, D., de Koning, H. P. and Field, M. C. (2016) Exploiting the Achilles' heel of membrane trafficking in trypanosomes. Current Opinion in Microbiology, 34, pp. 97-103. (doi: 10.1016/j.mib.2016.08.005) (PMID:27614711) (PMCID:PMC5176092)
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Abstract
Pathogenic protozoa are evolutionarily highly divergent from their metazoan hosts, reflected in many aspects of their biology. One particularly important parasite taxon is the trypanosomatids. Multiple transmission modes, distinct life cycles and exploitation of many host species attests to great prowess as parasites, and adaptability for efficient, chronic infection. Genome sequencing has begun uncovering how trypanosomatids are well suited to parasitism, and recent genetic screening and cell biology are revealing new aspects of how to control these organisms and prevent disease. Importantly, several lines of evidence suggest that membrane transport processes are central for the sensitivity towards several frontline drugs.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | De Koning, Professor Harry |
Authors: | Zoltner, M., Horn, D., de Koning, H. P., and Field, M. C. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Current Opinion in Microbiology |
Publisher: | Elsevier |
ISSN: | 1369-5274 |
ISSN (Online): | 1879-0364 |
Published Online: | 09 September 2016 |
Copyright Holders: | Copyright © 2016 The Authors |
First Published: | First published in Current Opinion in Microbiology 34:97-103 |
Publisher Policy: | Reproduced under a Creative Commons License |
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