Taylor, P., Page, A. P., Kontopidis, G., Husi, H. and Walkinshaw, M. D. (1998) The X-ray structure of a divergent cyclophilin from the nematode parasite Brugia malayi. FEBS Letters, 425(2), pp. 361-366. (doi: 10.1016/S0014-5793(98)00264-6) (PMID:9559680)
Full text not currently available from Enlighten.
Abstract
A structure of residues 1-177 of the cyclophilin domain of a large divergent cyclophilin from the filarial nematode parasite Brugia malayi has been crystallised and solved in two different crystal forms. The active site has a similar structure to that of human cyclophilin A. Two of the 13 residues important in forming the human cyclophilin A/cyclosporin A complex are altered in the B. malayi cyclophilin and explain the relatively poor inhibition of peptidyl prolyl isomerase activity by cyclosporin A.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Husi, Dr Holger |
| Authors: | Taylor, P., Page, A. P., Kontopidis, G., Husi, H., and Walkinshaw, M. D. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | FEBS Letters |
| Publisher: | Elsevier |
| ISSN: | 0014-5793 |
| ISSN (Online): | 1873-3468 |
University Staff: Request a correction | Enlighten Editors: Update this record
Altmetric
Altmetric