Clinical cardiovascular proteomics

Currie, G. , Matt, P. and Delles, C. (2016) Clinical cardiovascular proteomics. In: Agnetti, G., Lindsey, M. L. and Foster, D. B. (eds.) Manual of Cardiovascular Proteomics. Springer, pp. 389-414. ISBN 9783319318264 (doi: 10.1007/978-3-319-31828-8_17)

Abstract

Proteomics has the potential to be translated from a research environment to clinical practice. In the first instance the discovery of novel disease pathways and definition of druggable targets are promises of clinical proteomics. In parallel, clinical proteomics will define new protein-based biomarkers for molecular definition of disease, diagnosis of disease and prediction of events. In cardiovascular medicine the potential applications are manifold and examples are already available for conditions throughout the cardiovascular continuum from early risk factors to intermediate traits and advanced disease, all of which have been subject to proteomic studies. Despite the recent progress most of the available data do not fulfil criteria for novel biomarkers for cardiovascular diseases that are clinically applicable. Studies have been small, findings have not been reproduced in independent cohorts, plausible links to pathophysiology are not always present and sophisticated technical and bioinformatic requirements in proteomics pose challenges to translation of research findings to clinical cardiovascular medicine. Better standardisation of experiments, coordinated research efforts and close collaboration between clinicians and basic sciences will help to ask the right questions and provide the right answers and solutions in the near future.

• Item Type: Book Sections
• Status: Published
• Glasgow Author(s) Enlighten ID: Delles, Professor Christian and Currie, Dr Gemma
• Authors: Currie, G., Matt, P., and Delles, C.
• Subjects: R Medicine > R Medicine (General)
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Publisher: Springer
• ISBN: 9783319318264