Moulisova, V. , Sebestian, J., Jedlickova, O., Jegorov, A. and Sebestianova, S. (2006) Replacement of cyclosporin A from its binding to hepatocyte plasma membrane by silymarin flavonoids. Letters in Drug Design and Discovery, 3(6), pp. 429-435. (doi: 10.2174/157018006777805567)
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Abstract
Interactions between cyclosporin A and three silymarin flavonoids (silybin, silydianin, and silychristin) were studied on the rat hepatocyte plasma membrane using the replacement of [3H]cyclosporin A by silymarin flavonoids. It was found that flavonoids significantly replaced CsA from its binding to the rat hepatocyte plasma membrane. It seems that these two types of compounds are competitors at the same binding site of the plasma membrane receptor.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Moulisova, Dr Vladimira |
| Authors: | Moulisova, V., Sebestian, J., Jedlickova, O., Jegorov, A., and Sebestianova, S. |
| College/School: | College of Science and Engineering > School of Engineering > Biomedical Engineering |
| Journal Name: | Letters in Drug Design and Discovery |
| Publisher: | Bentham Science Publishers |
| ISSN: | 1570-1808 |
| ISSN (Online): | 1875-628X |
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