Caldwell, R. G., Wilson, J. B. , Anderson, S. J. and Longnecker, R. (1998) Epstein-Barr virus LMP2A drives B cell development and survival in the absence of normal B cell receptor signals. Immunity, 9(3), pp. 405-411. (doi: 10.1016/S1074-7613(00)80623-8) (PMID:9768760)
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Abstract
Epstein-Barr virus (EBV) establishes a persistent latent infection in peripheral B lymphocytes in humans and is associated with a variety of malignancies and proliferative disorders. Latent membrane protein 2A (LMP2A) is one of only two viral proteins expressed in latently infected B lymphocytes in vivo. LMP2A blocks B cell receptor (BCR) signal transduction in vitro by binding the Syk and Lyn protein tyrosine kinases. To analyze the significance of LMP2A expression in vivo, transgenic mice with B cell lineage expression of LMP2A were generated. LMP2A expression results in the bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin-negative cells to colonize peripheral lymphoid organs, indicating that LMP2A possesses a constitutive signaling activity in nontransformed cells.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Wilson, Professor Joanna |
| Authors: | Caldwell, R. G., Wilson, J. B., Anderson, S. J., and Longnecker, R. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
| Journal Name: | Immunity |
| Publisher: | Elsevier |
| ISSN: | 1074-7613 |
| ISSN (Online): | 1097-4180 |
| Published Online: | 11 April 2001 |
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