Flynn, J.N., Keating, P., Hosie, M.J. , Mackett, M., Stephens, E.B., Beatty, J.A., Neil, J.C. and Jarrett, O. (1996) Env-specific CTL predominate in cats protected from feline immunodeficiency virus infection by vaccination. Journal of Immunology, 157(8), pp. 3658-65. (PMID:8871667)
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Publisher's URL: http://jvi.asm.org/content/70/11/7561
Abstract
Animal models of HIV-1 have a key role to play in elucidation of the cellular mechanisms responsible for protective immunity. Vaccination of domestic cats with whole inactivated feline immunodeficiency virus (FIV) elicits virus-neutralizing Abs and virus-specific CTL in the peripheral blood and lymphoid organs and affords protection from homologous virus challenge. In the present study we confirm the induction of virus-specific CTL following immunization with whole inactivated FIV vaccine and demonstrate that cats are protected for up to 1 yr following vaccination. Long term protection in vaccinated cats correlates with both higher levels of FIV Env-specific CTL in the peripheral blood following vaccination and the presence of FIV Env-specific memory CD8+ CTL in the lymph nodes, which persist for up to 1 yr following challenge in the absence of detectable virus. The CTL responses observed in vaccinated protected cats differ qualitatively from those in FIV-infected cats. The latter cats either do not generate a memory CTL response or exhibit a Gag-specific memory CTL response. These results show that the protective immunity observed in whole inactivated virus-vaccinated cats is associated with the induction of high levels of Env-specific CTL activity.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Hosie, Professor Margaret and Jarrett, Professor James and Neil, Professor James |
Authors: | Flynn, J.N., Keating, P., Hosie, M.J., Mackett, M., Stephens, E.B., Beatty, J.A., Neil, J.C., and Jarrett, O. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
Journal Name: | Journal of Immunology |
ISSN: | 0022-1767 |
ISSN (Online): | 1872-7905 |
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