Cigarette smoking and gastric cancer in the stomach cancer pooling (StoP) project

Praud, D. et al. (2018) Cigarette smoking and gastric cancer in the stomach cancer pooling (StoP) project. European Journal of Cancer Prevention, 27(2), pp. 124-133. (doi: 10.1097/CEJ.0000000000000290) (PMID:27560662)

Abstract

Tobacco smoking is a known cause of gastric cancer, but several aspects of the association remain imprecisely quantified. We examined the relation between cigarette smoking and the risk of gastric cancer using a uniquely large dataset of 23 epidemiological studies within the ‘Stomach cancer Pooling (StoP) Project’, including 10 290 cases and 26 145 controls. We estimated summary odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) by pooling study-specific ORs using random-effects models. Compared with never smokers, the ORs were 1.20 (95% CI: 1.09–1.32) for ever, 1.12 (95% CI: 0.99–1.27) for former, and 1.25 (95% CI: 1.11–1.40) for current cigarette smokers. Among current smokers, the risk increased with number of cigarettes per day to reach an OR of 1.32 (95% CI: 1.10–1.58) for smokers of more than 20 cigarettes per day. The risk increased with duration of smoking, to reach an OR of 1.33 (95% CI: 1.14–1.54) for more than 40 years of smoking and decreased with increasing time since stopping cigarette smoking (P for trend<0.01) and became similar to that of never smokers 10 years after stopping. Risks were somewhat higher for cardia than noncardia gastric cancer. Risks were similar when considering only studies with information on Helicobacter pylori infection and comparing all cases to H. pylori+ controls only. This study provides the most precise estimate of the detrimental effect of cigarette smoking on the risk of gastric cancer on the basis of individual data, including the relationship with dose and duration, and the decrease in risk following stopping smoking.

• Item Type: Articles
• Additional Information: This project was supported by the Italian Ministry of Health (Young Researchers, GR-2011-02347943 to S.B.; and General Directorate of European and International Relations), the Fondazione Italiana per la Ricerca sul Cancro (FIRC), and the Associazione Italiana per la Ricerca sul Cancro, project no. 16715 (Investigator Grant). Matteo Rota and Delphine Praud were supported by a fellowship from the FIRC. Bárbara Peleteiro was supported by an individual grant from the ‘Fundação para a Ciência e a Tecnologia’ (SFRH/BPD/75918/2011).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Derakhshan, Professor Mohammad
• Authors: Praud, D., Rota, M., Pelucchi, C., Bertuccio, P., Rosso, T., Galeone, C., Zhang, Z.-F., Matsuo, K., Ito, H., Hu, J., Johnson, K. C., Yu, G.-P., Palli, D., Ferraroni, M., Muscat, J., Lunet, N., Peleteiro, B., Malekzadeh, R., Ye, W., Song, H., Zaridze, D., Maximovitch, D., Aragonés, N., Castaño-Vinyals, G., Vioque, J., Navarrete-Muñoz, E. M., Pakseresht, M., Pourfarzi, F., Wolk, A., Orsini, N., Bellavia, A., Håkansson, N., Mu, L., Pastorino, R., Kurtz, R. C., Derakhshan, M. H., Lagiou, A., Lagiou, P., Boffetta, P., Boccia, S., Negri, E., and La Vecchia, C.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: European Journal of Cancer Prevention
• Publisher: Lippincott Williams & Wilkins
• ISSN: 0959-8278
• ISSN (Online): 1473-5709
• Published Online: 24 August 2016
• Copyright Holders: Copyright © 2016 Wolters Kluwer Health, Inc.
• First Published: First published in European Journal of Cancer Prevention 27(2):124-133
• Publisher Policy: Reproduced in accordance with the publisher copyright policy