Productive infection of T-helper lymphocytes with feline immunodeficiency virus is accompanied by reduced expression of CD4

Willett, B.J. , Hosie, M.J. , Dunsford, T.H., Neil, J.C. and Jarrett, O. (1991) Productive infection of T-helper lymphocytes with feline immunodeficiency virus is accompanied by reduced expression of CD4. AIDS, 5(12), pp. 1469-75. (PMID:1687647)

Abstract

An antigen-specific feline T-lymphocyte cell line (Q201) was generated and infected in vitro with the feline immunodeficiency virus (FIV). Syncytium formation and the release of the viral core protein p24 into culture fluid were accompanied by a reduction in expression of the CD4 surface antigen. The reduction in CD4 expression was transient, the resulting persistently infected population of cells expressing levels of CD4 comparable to those observed prior to infection. Persistently infected cells gradually lost expression of major histocompatibility antigen (MHC) class II while maintaining pre-infection levels of expression of CD4, MHC class I, CD18 or CD29.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Hosie, Professor Margaret and Willett, Professor Brian and Neil, Professor James
• Authors: Willett, B.J., Hosie, M.J., Dunsford, T.H., Neil, J.C., and Jarrett, O.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity; College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research
• Journal Name: AIDS
• Publisher: Lippincott Williams & Wilkins
• ISSN: 0269-9370