Baek, D. J., MacRitchie, N., Pyne, N. J., Pyne, S. and Bittman, R. (2013) Synthesis of selective inhibitors of sphingosine kinase 1. Chemical Communications, 49(21), pp. 2136-2138. (doi: 10.1039/C3CC00181D) (PMID:23388656) (PMCID:PMC3608193)
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Abstract
Sphingosine kinase isoform 1 (SK1) inhibitors may serve as therapeutic agents for proliferative diseases, including hypertension. We synthesized a series of sphingosine-based SK1-selective inhibitors, the most potent of which is RB-005 (IC50 = 3.6 μM), which also induced proteasomal degradation of SK1 in human pulmonary arterial smooth muscle cells.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | MacRitchie, Dr Neil |
| Authors: | Baek, D. J., MacRitchie, N., Pyne, N. J., Pyne, S., and Bittman, R. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Chemical Communications |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1359-7345 |
| ISSN (Online): | 1364-548X |
| Published Online: | 28 January 2013 |
| Copyright Holders: | Copyright © 2013 The Royal Society of Chemistry |
| First Published: | First published in Chemical Communications 49(21): 2136-2138 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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