Morris, J. S. (2016) Genomic and proteomic profiling for cancer diagnosis in dogs. Veterinary Journal, 215, pp. 101-109. (doi: 10.1016/j.tvjl.2016.01.003) (PMID:26848120)
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123782.pdf - Accepted Version 225kB |
Abstract
Global gene expression, whereby tumours are classified according to similar gene expression patterns or ‘signatures’ regardless of cell morphology or tissue characteristics, is being increasingly used in both the human and veterinary fields to assist in cancer diagnosis and prognosis. Many studies on canine tumours have focussed on RNA expression using techniques such as microarrays or next generation sequencing. However, proteomic studies combining two-dimensional polyacrylamide gel electrophoresis or two-dimensional differential gel electrophoresis with mass spectrometry have also provided a wealth of data on gene expression in tumour tissues. In addition, proteomics has been instrumental in the search for tumour biomarkers in blood and other body fluids.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Morris, Professor Joanna |
| Authors: | Morris, J. S. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Veterinary Journal |
| Publisher: | Elsevier |
| ISSN: | 1090-0233 |
| ISSN (Online): | 1532-2971 |
| Published Online: | 12 January 2016 |
| Copyright Holders: | Copyright © 2016 Elsevier |
| First Published: | First published in Veterinary Journal 215:101-109 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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