Synthesis of six novel N,N-dialkyl derivatives of spermidine and effects on growth of the fungal plant pathogen Pyrenophora avenae

Mackintosh, C.A., Slater, L.A., Walters, D.R. and Robins, D.J. (2001) Synthesis of six novel N,N-dialkyl derivatives of spermidine and effects on growth of the fungal plant pathogen Pyrenophora avenae. FEMS Microbiology Letters, 202(2), pp. 221-225. (doi: 10.1111/j.1574-6968.2001.tb10807.x)

Abstract

Six novel <i>N,N</i>-dialkyl derivatives of spermidine were synthesised and examined for activity against the oat stripe pathogen <i>Pyrenophora avenae</i>. Two of these spermidine analogues, <i>N,N</i>-dimethyl-<i>N</i>¹-(3-aminopropyl)-1,3-diaminopropane trihydrochloride (27) and <i>N,N</i>-dimethyl-<i>N</i>¹-(3-aminopropyl)-1,4-diaminobutane trihydrochloride (28), reduced radial extension of <i>P. avenae</i> on plates when used at 2 mM, and caused more substantial reductions in fungal growth in liquid culture when used at 1 mM. Preliminary data suggest that neither compound affected polyamine biosynthesis, determined by following the incorporation of label from ornithine into polyamines and examining intracellular polyamine concentrations in fungal tissue.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Robins, Prof David
• Authors: Mackintosh, C.A., Slater, L.A., Walters, D.R., and Robins, D.J.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: FEMS Microbiology Letters
• Publisher: Wiley
• ISSN: 0378-1097
• ISSN (Online): 1574-6968
• Published Online: 09 January 2006