Hsp90 inhibitors in parasitic nematodes: prospects and challenges

Devaney, E. and Gillan, V. (2016) Hsp90 inhibitors in parasitic nematodes: prospects and challenges. Current Topics in Medicinal Chemistry, 16(25), pp. 2805-2811. (doi: 10.2174/1568026616666160413140502) (PMID:27072703)

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Hsp90 inhibitors are well characterized in relation to their effects in a variety of tumors, with several inhibitors in various phases of clinical development. In recent years, the same inhibitor classes have been tested for efficacy in other systems, such as Alzheimer's disease and a variety of infectious disease models, including fungal and parasitic targets. In this article we discuss the repurposing of Hsp90 inhibitors for parasitic disease with a focus on parasitic nematode infections. We summarize the data that indicate that Hsp90 is functionally diverse in different nematode species and we discuss the challenges and prospects for developing these inhibitors as next generation chemotherapeutic tools.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Devaney, Professor Eileen and Gillan, Dr Victoria
Authors: Devaney, E., and Gillan, V.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Current Topics in Medicinal Chemistry
Publisher:Bentham Science Publishers Ltd.
ISSN (Online):1873-4294
Copyright Holders:Copyright © 2016 Bentham Science Publishers
First Published:First published in Current Topics in Medicinal Chemistry 16(25):2805-2811
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
441591A comparative analysis of Hsp90 its possible role in drug resistance in nematode parasitesEileen DevaneyBiotechnology and Biological Sciences Research Council (BBSRC)BB/E013473/1III - PARASITOLOGY
398951Hsp90 as a molecular target in lymphatic filariasisEileen DevaneyWellcome Trust (WELLCOME)076734/Z/05/ZIII - PARASITOLOGY