Recovered src genes are polymorphic and contain host markers

Vigne, R., Neil, J. C. , Breitman, M. L. and Vogt, P. K. (1980) Recovered src genes are polymorphic and contain host markers. Virology, 105(1), pp. 71-85. (doi: 10.1016/0042-6822(80)90157-9)

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Analysis of recovered sarcoma viruses (rASV) and their parental sarcoma virus SR-D by oligonucleotide fingerprinting revealed multiple differences in the src region of the viral genomes. This heterogeneity was further investigated by tryptic peptide mapping of the in vitro translated products of rASV and SR-D RNA. No differences were found in the pr76gag proteins encoded by the various rASVs or SR-D, but the p60src proteins showed considerable variation. The p60src proteins of rASV could be distinguished from that of SR-D on the basis of their mobility in SDS-polyacrylamide gels. Furthermore, two peptides which were absent from SR-D but consistently found in rASV p60src proteins were also demonstrated in a tryptic peptide map of the cellular src-related protein, p60sarc. These results provide strong support for the hypothesis that rASV arose by recombination of residual viral src sequences with cellular src-related sequences.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Neil, Professor James
Authors: Vigne, R., Neil, J. C., Breitman, M. L., and Vogt, P. K.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Virology
ISSN (Online):1096-0341
Published Online:01 February 2004

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