Neutrophils in cancer: neutral no more

Coffelt, S. B. , Wellenstein, M. D. and de Visser, K. E. (2016) Neutrophils in cancer: neutral no more. Nature Reviews Cancer, 16(7), pp. 431-446. (doi: 10.1038/nrc.2016.52) (PMID:27282249)

Abstract

Neutrophils are indispensable antagonists of microbial infection and facilitators of wound healing. In the cancer setting, a newfound appreciation for neutrophils has come into view. The traditionally held belief that neutrophils are inert bystanders is being challenged by the recent literature. Emerging evidence indicates that tumours manipulate neutrophils, sometimes early in their differentiation process, to create diverse phenotypic and functional polarization states able to alter tumour behaviour. In this Review, we discuss the involvement of neutrophils in cancer initiation and progression, and their potential as clinical biomarkers and therapeutic targets.

• Item Type: Articles
• Additional Information: S.B.C. is supported by a Marie Curie Intra-European Fellowship (BMDCMET 275610). Research in the K.d.V lab is supported by a European Research Council Consolidator award (InflaMet 615300), the European Union (FP7 MCA-ITN 317445 TIMCC), the Dutch Cancer Society (2011-5004), Worldwide Cancer Research (AICR 11-0677), the Netherlands Organization for Scientific Research NWO VIDI (917.96.307) and the Beug Foundation for Metastasis Research.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Coffelt, Professor Seth
• Authors: Coffelt, S. B., Wellenstein, M. D., and de Visser, K. E.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Nature Reviews Cancer
• Publisher: Nature Publishing Group
• ISSN: 1474-175X
• ISSN (Online): 1474-1768
• Published Online: 10 June 2016
• Copyright Holders: Copyright © 2016 Nature Publications
• First Published: First published in Nature Reviews Cancer 16(7):431-446
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher