McAulay, K.A. and Jarrett, R.F. (2015) Human leukocyte antigens and genetic susceptibility to lymphoma. Tissue Antigens, 86(2), pp. 98-113. (doi: 10.1111/tan.12604) (PMID:26189878)
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Abstract
Familial aggregation, coupled with ethnic variation in incidence, suggests that inherited susceptibility plays a role in the development of lymphoma, and the search for genetic risk factors has highlighted the contribution of the human leukocyte antigen (HLA) complex. In a landmark study published almost 50 years ago, Hodgkin lymphoma (HL) was the first disease to be associated with HLA variation. It is now clear that Epstein-Barr virus (EBV)-positive and -negative HL are strongly associated with specific HLA polymorphisms but these differ by EBV status of the tumours. HLA class I alleles are consistently associated with EBV-positive HL while a polymorphism in HLA class II is the strongest predictor of risk of EBV-negative HL. Recent investigations, particularly genome-wide association studies (GWAS), have also revealed associations between HLA and common types of non-Hodgkin lymphoma (NHL). Follicular lymphoma is strongly associated with two distinct haplotypes in HLA class II whereas diffuse large B-cell lymphoma is most strongly associated with HLA-B*08. Although chronic lymphocytic leukaemia is associated with variation in HLA class II, the strongest signals in GWAS are from non-HLA polymorphisms, suggesting that inherited susceptibility is explained by co-inheritance of multiple low risk variants. Associations between B-cell derived lymphoma and HLA variation suggest that antigen presentation, or lack of, plays an important role in disease pathogenesis but the precise mechanisms have yet to be elucidated.
| Item Type: | Articles (Other) |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Jarrett, Professor Ruth and McAulay, Dr Karen |
| Authors: | McAulay, K.A., and Jarrett, R.F. |
| Subjects: | R Medicine > RB Pathology R Medicine > RZ Other systems of medicine |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Tissue Antigens |
| Publisher: | Wiley |
| ISSN: | 0001-2815 |
| ISSN (Online): | 1399-0039 |
| Published Online: | 20 July 2015 |
| Copyright Holders: | Copyright © 2015 John Wiley and Sons A/S |
| First Published: | First published in Tissue Antigens 86(2): 98-113 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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