The resting human brain and motor learning

Albert, N. B., Robertson, E. M. and Miall, R. C. (2009) The resting human brain and motor learning. Current Biology, 19(12), pp. 1023-1027. (doi: 10.1016/j.cub.2009.04.028) (PMID:19427210) (PMCID:PMC2701987)

Abstract

Functionally related brain networks are engaged even in the absence of an overt behavior. The role of this resting state activity, evident as low-frequency fluctuations of BOLD (see [1] for review, [2-4]) or electrical [5, 6] signals, is unclear. Two major proposals are that resting state activity supports introspective thought or supports responses to future events [7]. An alternative perspective is that the resting brain actively and selectively processes previous experiences [8]. Here we show that motor learning can modulate subsequent activity within resting networks. BOLD signal was recorded during rest periods before and after an 11 min visuomotor training session. Motor learning but not motor performance modulated a fronto-parietal resting state network (RSN). Along with the fronto-parietal network, a cerebellar network not previously reported as an RSN was also specifically altered by learning. Both of these networks are engaged during learning of similar visuomotor tasks [9-22]. Thus, we provide the first description of the modulation of specific RSNs by prior learning--but not by prior performance--revealing a novel connection between the neuroplastic mechanisms of learning and resting state activity. Our approach may provide a powerful tool for exploration of the systems involved in memory consolidation.

• Item Type: Articles
• Additional Information: This work was supported by the Wellcome Trust (069439, R.C.M.) and by the U.S. National Institutes of Health (R01 NS051446, E.M.R.).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Robertson, Professor Edwin
• Authors: Albert, N. B., Robertson, E. M., and Miall, R. C.
• College/School: College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
• Journal Name: Current Biology
• Publisher: Elsevier (Cell Press)
• ISSN: 0960-9822
• ISSN (Online): 1879-0445
• Published Online: 07 May 2009
• Copyright Holders: Copyright: © 2009 Elsevier Ltd
• First Published: First published in Current Biology 19(12)2009
• Publisher Policy: Reproduced under a creative commons license