Caris-Veyrat, C., Garcia, A. L. , Reynaud, E., Lucas, R., Aydemir, G. and Rühl, R. (2017) A review about lycopene-induced nuclear hormone receptor signalling in inflammation and lipid metabolism via still unknown endogenous apo-10´-lycopenoids. International Journal for Vitamin and Nutrition Research, 86, pp. 62-70. (doi: 10.1024/0300-9831/a000404) (PMID:29052471)
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Abstract
Lycopene is the red pigment in tomatoes and tomato products and is an important dietary carotenoid found in the human organism. Lycopene-isomers, oxidative lycopene metabolites and apo-lycopenoids are found in the food matrix. Lycopene intake derived from tomato consumption is associated with alteration of lipid metabolism and a lower incidence of cardiovascular diseases (CVD). Lycopene is mainly described as a potent antioxidant but novel studies are shifting towards its metabolites and their capacity to mediate nuclear receptor signalling. Di-/tetra-hydro-derivatives of apo-10´-lycopenoic acid and apo-15´-lycopenoic acids are potential novel endogenous mammalian lycopene metabolites which may act as ligands for nuclear hormone mediated activation and signalling. In this review, we postulate that complex lycopene metabolism results in various lycopene metabolites which have the ability to mediate transactivation of various nuclear hormone receptors like RARs, RXRs and PPARs. A new mechanistic explanation of how tomato consumption could positively modulate inflammation and lipid metabolism is discussed.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Garcia, Dr Ada |
| Authors: | Caris-Veyrat, C., Garcia, A. L., Reynaud, E., Lucas, R., Aydemir, G., and Rühl, R. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | International Journal for Vitamin and Nutrition Research |
| Publisher: | Hans Huber Publisher |
| ISSN: | 0300-9831 |
| ISSN (Online): | 1664-2821 |
| Published Online: | 20 October 2017 |
| Copyright Holders: | Copyright © 2016 Hans Huber Publisher |
| First Published: | First published in International Journal for Vitamin and Nutrition Research 86:62-70 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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