Chadzynski, G. L., Pohmann, R., Shajan, G. , Kolb, R., Bisdas, S., Klose, U. and Scheffler, K. (2015) In vivo proton magnetic resonance spectroscopic imaging of the healthy human brain at 9.4 T: initial experience. Magnetic Resonance Materials in Physics, Biology and Medicine, 28(3), pp. 239-249. (doi: 10.1007/s10334-014-0460-5) (PMID:25248946)
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Abstract
Object: In this study, the feasibility of in vivo proton magnetic resonance spectroscopic imaging (1H MRSI) of the healthy human brain at a field strength of 9.4 T, using conventional acquisition techniques, is examined and the initial experience is summarized. Materials and methods: MRSI measurements were performed on a 9.4 T MR scanner (Siemens, Erlangen, Germany) equipped with head-only gradient insert (AC84, Siemens) and custom-developed, 8-channel transmit/24-channel receive, and 16-channel transmit/31-channel receive coils. Spectra were acquired from the superior part of the human brain with a modified STEAM sequence. Spectral quantification was done with LCModel software. Results: Reasonable quality and signal-to-noise ratio of the acquired spectra allowed reliable quantification of 12 metabolites (Cramer-Rao lower bounds < 20 %), some of which may be difficult to quantify at field strengths below 7 T due to overlapping resonances or low concentrations. Conclusion: While further developments are necessary to minimize chemical shift displacement and homogeneity of the transmit field, it is demonstrated that in vivo 1H MRSI at a field strength of 9.4 T is possible. However, further studies applying up-to-date techniques to overcome high-field specific problems are needed in order to assess the potential gain in sensitivity that may be offered by MRSI at 9.4 T.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Gunamony, Dr Shajan |
Authors: | Chadzynski, G. L., Pohmann, R., Shajan, G., Kolb, R., Bisdas, S., Klose, U., and Scheffler, K. |
College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
Journal Name: | Magnetic Resonance Materials in Physics, Biology and Medicine |
Publisher: | Springer Berlin Heidelberg |
ISSN: | 0968-5243 |
ISSN (Online): | 1352-8661 |
Published Online: | 24 September 2014 |
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