Quantitative and functional pulsed arterial spin labeling in the human brain at 9.4 t

Bause, J., Ehses, P., Mirkes, C., Shajan, G. , Scheffler, K. and Pohmann, R. (2016) Quantitative and functional pulsed arterial spin labeling in the human brain at 9.4 t. Magnetic Resonance in Medicine, 75(3), pp. 1054-1063. (doi: 10.1002/mrm.25671) (PMID:25940006)

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Purpose: The feasibility of multislice pulsed arterial spin labeling (PASL) of the human brain at 9.4 T was investigated. To demonstrate the potential of arterial spin labeling (ASL) at this field strength, quantitative, functional, and high-resolution (1.05 × 1.05 × 2 mm3) ASL experiments were performed. Methods: PASL was implemented using a numerically optimized adiabatic inversion pulse and presaturation scheme. Quantitative measurements were performed at 3 T and 9.4 T and evaluated on a voxel-by-voxel basis. In a functional experiment, activation maps obtained with a conventional blood-oxygen-level-dependent (BOLD)-weighted sequence were compared with a functional ASL (fASL) measurement. Results: Quantitative measurements revealed a 23% lower perfusion in gray matter and 17% lower perfusion in white matter at 9.4 T compared with 3 T. Furthermore almost identical transit delays and bolus durations were found at both field strengths whereas the calculated voxel volume corrected signal-to-noise ratio was 1.9 times higher at 9.4 T. This result was confirmed by the high-resolution experiment. The functional experiment yielded comparable activation maps for the fASL and BOLD measurements. Conclusion: Although PASL at ultrahigh field strengths is limited by high specific absorption rate, functional and quantitative perfusion-weighted images showing a high degree of detail can be obtained.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Gunamony, Dr Shajan
Authors: Bause, J., Ehses, P., Mirkes, C., Shajan, G., Scheffler, K., and Pohmann, R.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Magnetic Resonance in Medicine
ISSN (Online):1522-2594
Published Online:02 May 2015

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