Hong, X., van Dijk, E. M.P.H., Hall, S. R., Götte, J. B. , van Hulst, N. F. and Gersen, H. (2011) Background-free detection of single 5 nm nanoparticles through interferometric cross-polarization microscopy. Nano Letters, 11(2), pp. 541-547. (doi: 10.1021/nl1034489) (PMID:21204579)
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Abstract
Metal nanoparticles play a key role in sensing and imaging. Here we demonstrate the detection of metal particles down to 5 nm in size with a signal-to-noise ratio of ∼7 using interferometric cross-polarization microscopy at ultralow excitation powers (∼1 μW) compatible with single molecule detection. The method is background-free and induces no heating as it operates far from plasmonic resonance. The combination of unlimited observation time and protein-sized metal nanoparticles has great potential for biophysical applications.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Goette, Dr Joerg |
Authors: | Hong, X., van Dijk, E. M.P.H., Hall, S. R., Götte, J. B., van Hulst, N. F., and Gersen, H. |
College/School: | College of Science and Engineering > School of Physics and Astronomy |
Journal Name: | Nano Letters |
Publisher: | American Chemical Society |
ISSN: | 1530-6984 |
ISSN (Online): | 1530-6992 |
Published Online: | 04 January 2011 |
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