Manganas, P., MacPherson, L. and Tokatlidis, K. (2017) Oxidative protein biogenesis and redox regulation in the mitochondrial intermembrane space. Cell and Tissue Research, 367(1), pp. 43-57. (doi: 10.1007/s00441-016-2488-5) (PMID:27632163) (PMCID:PMC5203823)
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Abstract
Mitochondria are organelles that play a central role in cellular metabolism, as they are responsible for processes such as iron/sulfur cluster biogenesis, respiration and apoptosis. Here, we describe briefly the various protein import pathways for sorting of mitochondrial proteins into the different subcompartments, with an emphasis on the targeting to the intermembrane space. The discovery of a dedicated redox-controlled pathway in the intermembrane space that links protein import to oxidative protein folding raises important questions on the redox regulation of this process. We discuss the salient features of redox regulation in the intermembrane space and how such mechanisms may be linked to the more general redox homeostasis balance that is crucial not only for normal cell physiology but also for cellular dysfunction.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Manganas, Phanee and Tokatlidis, Professor Kostas |
Authors: | Manganas, P., MacPherson, L., and Tokatlidis, K. |
College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
Journal Name: | Cell and Tissue Research |
Publisher: | Springer |
ISSN: | 0302-766X |
ISSN (Online): | 1432-0878 |
Published Online: | 08 September 2016 |
Copyright Holders: | Copyright © 2016 The Authors |
First Published: | First published in Cell and Tissue Research 367(1): 43-57 |
Publisher Policy: | Reproduced under a Creative Commons License |
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