Oxidative protein biogenesis and redox regulation in the mitochondrial intermembrane space

Manganas, P., MacPherson, L. and Tokatlidis, K. (2017) Oxidative protein biogenesis and redox regulation in the mitochondrial intermembrane space. Cell and Tissue Research, 367(1), pp. 43-57. (doi: 10.1007/s00441-016-2488-5) (PMID:27632163) (PMCID:PMC5203823)

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Mitochondria are organelles that play a central role in cellular metabolism, as they are responsible for processes such as iron/sulfur cluster biogenesis, respiration and apoptosis. Here, we describe briefly the various protein import pathways for sorting of mitochondrial proteins into the different subcompartments, with an emphasis on the targeting to the intermembrane space. The discovery of a dedicated redox-controlled pathway in the intermembrane space that links protein import to oxidative protein folding raises important questions on the redox regulation of this process. We discuss the salient features of redox regulation in the intermembrane space and how such mechanisms may be linked to the more general redox homeostasis balance that is crucial not only for normal cell physiology but also for cellular dysfunction.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Manganas, Phanee and Tokatlidis, Professor Kostas
Authors: Manganas, P., MacPherson, L., and Tokatlidis, K.
College/School:College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
Journal Name:Cell and Tissue Research
ISSN (Online):1432-0878
Published Online:08 September 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Cell and Tissue Research 367(1): 43-57
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
459161Scottish Universities Life Sciences Alliance (SULSA)- Enhancing Research Competitiveness Pooling StreamPaul HaganScottish Funding Council (SFC)HR07019SCHOOL OF LIFE SCIENCES
624931Oxidative Folding and Redox Signalling in the Mitochondria Intermembrane Space.Konstantinos TokatlidisRoyal Society (ROYSOC)WM120111RI MOLECULAR CELL & SYSTEMS BIOLOGY