A dual sensor spin trap for use with EPR spectroscopy

Caldwell, S. T., Quin, C., Edge, R. and Hartley, R. C. (2007) A dual sensor spin trap for use with EPR spectroscopy. Organic Letters, 9(18), pp. 3499-3502. (doi:10.1021/ol071285o)

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Publisher's URL: http://dx.doi.org/10.1021/ol071285o

Abstract

Redox active metal ions, carbon-centered radicals, and oxygen-centered radicals are important to oxidative stress. A radical detector combining a nitrone spin trap, a phenol, and a cyclopropane radical clocklike unit was prepared and used with EPR spectroscopy to detect and distinguish between hydroxyl radicals, methyl radicals, and iron(III) ions. Iron(III) reacts with the phenol unit inducing opening of the cyclopropane ring and cyclization to generate a stable nitroxyl radical.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Quin, Miss Caroline and Hartley, Professor Richard
Authors: Caldwell, S. T., Quin, C., Edge, R., and Hartley, R. C.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Organic Letters
Journal Abbr.:Org. Lett.
ISSN:1523-7060
ISSN (Online):1523-7052
Published Online:01 August 2007

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
397491Adventurous research in chemistry: from proteins to surfaces (pushing the limits of powder diffraction; towards protein crystallography on a laboratory powder diffractometer)C GilmoreEngineering & Physical Sciences Research Council (EPSRC)EP/C532236/1Chemistry