Stevenson, L., Pimlott, S. L. and Sutherland, A. (2007) A novel approach for the synthesis of the peripheral benzodiazepine receptor ligand, PK11195. Tetrahedron Letters, 48(40), pp. 7137-7139. (doi: 10.1016/j.tetlet.2007.07.203)
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Abstract
A new synthesis of the peripheral benzodiazepine receptor ligand, PK11195 has been developed in only six-steps using a Heck-type reaction and a Suzuki coupling to effect the key transformations. The flexibility of this new approach is demonstrated by the synthesis of an iodo-analogue of PK11195 prepared from the corresponding bromide using a copper catalysed aromatic Finkelstein reaction.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Pimlott, Dr Sally and Sutherland, Professor Andrew |
| Authors: | Stevenson, L., Pimlott, S. L., and Sutherland, A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Tetrahedron Letters |
| Publisher: | Elsevier |
| ISSN: | 0040-4039 |
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