Comparison of statistical methods for assessing spatial correlations between maps of fifferent arterial properties

Rowland, E. M., Mohamied, Y., Yean Chooi, K., Bailey, E. L. and Weinberg, P. D. (2015) Comparison of statistical methods for assessing spatial correlations between maps of fifferent arterial properties. Journal of Biomechanical Engineering, 137(10), 101003. (doi: 10.1115/1.4031119) (PMID:26201866)

Abstract

Assessing the anatomical correlation of atherosclerosis with biomechanical localizing factors is hindered by spatial autocorrelation (SA), wherein neighboring arterial regions tend to have similar properties rather than being independent, and by the use of aggregated data, which artificially inflates correlation coefficients. Resampling data at lower resolution or reducing degrees-of-freedom in significance tests negated effects of SA but only in artificial situations where it occurred at a single length scale. Using Fourier or wavelet transforms to generate autocorrelation-preserving surrogate datasets, and thus to compute the null distribution, avoided this problem. Bootstrap methods additionally circumvented the errors caused by aggregating data. The bootstrap technique showed that wall shear stress (WSS) was significantly correlated with atherosclerotic lesion frequency and endothelial nuclear elongation, but not with the permeability of the arterial wall to albumin, in immature rabbits.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Bailey, Dr Emma
• Authors: Rowland, E. M., Mohamied, Y., Yean Chooi, K., Bailey, E. L., and Weinberg, P. D.
• Subjects: R Medicine > R Medicine (General)
• College/School: College of Medical Veterinary and Life Sciences > School of Life Sciences
• Journal Name: Journal of Biomechanical Engineering
• Publisher: American Society of Mechanical Engineers
• ISSN: 0148-0731
• ISSN (Online): 1528-8951
• Published Online: 06 August 2015