Millar, A., Mansfield, M. and Kinsella, J. (1998) Influence of timing of morphine administration on postoperative pain and analgesic consumption. British Journal of Anaesthesia, 81(3), pp. 373-376. (doi: 10.1093/bja/81.3.373) (PMID:9861123)
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Abstract
We have investigated if a pre-emptive dose of morphine, given 30 min before skin incision, influenced postoperative pain and morphine consumption after hysterectomy. In a prospective, randomized, double-blind, placebo-controlled clinical study, patients received morphine 0.3 mg kg-1 at induction of anaesthesia or 30 min later at skin incision. The primary endpoint was defined as 24-h morphine consumption via patient-controlled analgesia. We could not demonstrate any difference between the two groups in morphine consumption or pain scores, and we conclude that there was no evidence of pre-emptive analgesia in this study.
| Item Type: | Articles (Other) |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Kinsella, Professor John |
| Authors: | Millar, A., Mansfield, M., and Kinsella, J. |
| Subjects: | R Medicine > R Medicine (General) |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | British Journal of Anaesthesia |
| Publisher: | Oxford University Press |
| ISSN: | 0007-0912 |
| ISSN (Online): | 1471-6771 |
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