Proteinase-activated receptor 2 is involved in the behavioural changes associated with sickness behaviour

Abulkassim, R., Brett, R., MacKenzie, S. M. and Bushell, T. J. (2016) Proteinase-activated receptor 2 is involved in the behavioural changes associated with sickness behaviour. Journal of Neuroimmunology, 295-96, pp. 139-147. (doi: 10.1016/j.jneuroim.2016.04.016) (PMID:27235359)

Abstract

Proteinase-activated receptor-2 (PAR2) is widely expressed in the CNS but whether it plays a key role in inflammation-related behavioural changes remains unknown. Hence, in the present study we have examined whether PAR2 contributes to behaviour associated with systemic inflammation using PAR2 transgenic mice. The onset of sickness behaviour was delayed and the recovery accelerated in PAR2−/− mice in the LPS-induced model of sickness behaviour. In contrast, PAR2 does not contribute to behaviour under normal conditions. In conclusion, these data suggest that PAR2 does not contribute to behaviour in the normal healthy brain but it plays a role in inflammation-related behavioural changes.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: MacKenzie, Dr Scott
• Authors: Abulkassim, R., Brett, R., MacKenzie, S. M., and Bushell, T. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Journal of Neuroimmunology
• Publisher: Elsevier
• ISSN: 0165-5728
• ISSN (Online): 1872-8421
• Published Online: 27 April 2016
• Copyright Holders: Copyright © 2016 Elsevier
• First Published: First published in Journal of Neuroimmunology 295-96:139-147
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher