Characterisation of CorGlaes® Pure 107 fibres for biomedical applications

Colquhoun, R., Gadegaard, N. , Healy, D. M. and Tanner, K. E. (2016) Characterisation of CorGlaes® Pure 107 fibres for biomedical applications. Journal of Materials Science: Materials in Medicine, 27, 149. (doi: 10.1007/s10856-016-5752-z)

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A degradable ultraphosphate (55 mol % P2O5) quinternary phosphate glass composition has been characterised in terms of its chemical, mechanical and degradation properties both as a bulk material and after drawing into fibres. This glass formulation displayed a large processing window simplifying fibre drawing. The fibres displayed stiffness and strength of 65.5 ± 20.8 GPa and 426±143 MPa. While amorphous discs of the glass displayed a linear dissolution rate of 0.004 mg cm−2 h−1 at 37 °C, in a static solution with a reduction in media pH. Once drawn into fibres, the dissolution process dropped the pH to <2 in distilled water, phosphate buffer saline and corrected-simulated body fluid, displaying an autocatalytic effect with >90 % mass loss in 4 days, about seven times faster than anticipated for this solution rate. Only cell culture media was able to buffer the pH taking over a week for full fibre dissolution, however, still four times faster dissolution rate than as a bulk material. However, at early times the development of a HCA layer was seen indicating potential bioactivity. Thus, although initial analysis indicated potential orthopaedic implant applications, autocatalysis leads to accelerating degradation in vitro.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Tanner, Professor Kathleen and Gadegaard, Professor Nikolaj
Authors: Colquhoun, R., Gadegaard, N., Healy, D. M., and Tanner, K. E.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Journal of Materials Science: Materials in Medicine
ISSN (Online):1573-4838
Published Online:31 August 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Journal of Materials Science: Materials in Medicine 27:149
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
530321Collagen Based Micro-fabricated Scaffolds for Bone RegenerationK TannerEngineering & Physical Sciences Research Council (EPSRC)09001298/EP/H50ENG - BIOMEDICAL ENGINEERING