Clancy, J. A. , Lall, V. K. and Deuchars, S. A. (2011) Highlights in basic autonomic neurosciences: new avenues for the study of autonomic function in health and disease. Autonomic Neuroscience, 161(1-2), pp. 49-52. (doi: 10.1016/j.autneu.2011.02.002)
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Abstract
Sudden death accounts for 30–50% of total mortality in chronic heart failure (CHF) patients. The occurrence of sudden death in CHF exhibits a circadian periodicity and may be exacerbated by a morning peak in cardiac sympathetic activity. As amiodarone has been found to protect against cardiac events in CHF patients (Amiodarone trials meta-analysis investigators, 1997, Lancet, 350: 1417–1424), Ohori et al. investigated the effect of amiadarone treatment on circadian variation of cardiovascular autonomic control in rats with CHF. 24 h blood pressure (BP) telemetry was recorded in rats with CHF (induced by myocardial infarction 4 weeks previously; n = 16) and sham operated rats (n = 7). During the awakening period (16.00–20.00) heart rate (HR), BP and locomotor activity levels increased in both CHF and sham rats as expected. Power spectral analysis of low frequency blood pressure variability (LFdp) during this time demonstrated an increase in sympathetic activity in both groups and is comparable to the increase in sympathetic activity observed in humans in the early morning. In addition, compared to sham rats, the CHF rats exhibited decreases in high frequency heart rate variability indicating reduced vagal activity. These findings imply that CHF rats had a higher predominance of sympathetic activity during awakening than sham rats. The CHF rats underwent 3 weeks of either amiodarone treatment (50 mg/kg daily; n = 8) or saline administration (n = 8). After 3 weeks, BP telemetry was recorded again for 24 h and HR and autonomic function calculated. Rats were then euthanized and hearts were examined to determine infarct size. The results show that the transient increase in LFdp during awakening was significantly suppressed in amiodarone treated rats compared to saline treated rats following 3 weeks of treatment.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Clancy, Dr Jenny |
| Authors: | Clancy, J. A., Lall, V. K., and Deuchars, S. A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Life Sciences |
| Journal Name: | Autonomic Neuroscience |
| Publisher: | Elsevier |
| ISSN: | 1566-0702 |
| ISSN (Online): | 1872-7484 |
| Published Online: | 04 March 2011 |
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