Dichotomous relationship between age and 30-day death or rehospitalization in heart failure patients admitted with acute decompensated heart failure: results from the ASCEND-HF trial

Whellan, D. J., Stebbins, A., Hernandez, A. F., Ezekowitz, J. A., McMurray, J. J.V. , Mather, P. J., Hasselblad, V. and O'Connor, C. M. (2016) Dichotomous relationship between age and 30-day death or rehospitalization in heart failure patients admitted with acute decompensated heart failure: results from the ASCEND-HF trial. Journal of Cardiac Failure, 22(6), pp. 409-416. (doi: 10.1016/j.cardfail.2016.02.011) (PMID:26952241)

Abstract

Background: Younger age as an independent predictor of death or all-cause rehospitalization at 30 days post-randomization for hospitalized heart failure (HF) patients has not been well described. Methods and Results: ASCEND-HF enrolled 7141 hospitalized acute HF patients (categorized by age: <45, 45 to <55, 55 to <65, 65 to <75, and ≥75 years) and followed them for 30 days to assess clinical outcomes, which included death or rehospitalization. Patients 45 to <55 years had the lowest percentages of death (1.4%) and total rehospitalizations (10.7%); percentages increased for younger (3.0% and 12.2%, respectively, for age <45 y) and older (5.8% and 12.5%, respectively, for age ≥75 y) patients. For those rehospitalized, the total HF-induced readmissions were highest in the youngest (68%) and declined with increasing age (P = .03). Although patients ≥55 years of age were more likely to die or be rehospitalized within 30 days of randomization for each additional 10 years of life, those <55 years of age had a significant reduction in death or HF rehospitalization for each 10-year increase in age (similar findings for death and HF rehospitalization). Conclusions: There is a dichotomous relationship between age and risk of death or rehospitalization, and death or HF rehospitalization—risk decreases as age increases up to age 55 years, then increases after age 55 years.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: McMurray, Professor John
• Authors: Whellan, D. J., Stebbins, A., Hernandez, A. F., Ezekowitz, J. A., McMurray, J. J.V., Mather, P. J., Hasselblad, V., and O'Connor, C. M.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Journal of Cardiac Failure
• Publisher: Elsevier
• ISSN: 1071-9164
• Published Online: 04 March 2016