High yielding microbubble production method

Fiabane, J., Prentice, P. and Pancholi, K. (2016) High yielding microbubble production method. BioMed Research International, 2016, 3572827. (doi: 10.1155/2016/3572827) (PMID:27034935) (PMCID:PMC4789381)

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Microfluidic approaches to microbubble production are generally disadvantaged by low yield and high susceptibility to (micro)channel blockages. This paper presents an alternative method of producing microbubbles of 2.6 μm mean diameter at concentrations in excess of 30 × 106 mL−1. In this method, the nitrogen gas flowing inside the liquid jet is disintegrated into spray of microbubble when air surrounding this coflowing nitrogen gas-liquid jet passes through a 100 μm orifice at high velocity. Resulting microbubble foam has the polydispersity index of 16%. Moreover, a ratio of mean microbubble diameter to channel width ratio was found to be less than 0.025, which substantially alleviates the occurrence of blockages during production.

Item Type:Articles
Additional Information:The authors acknowledge support from EPSRC Grant EP/ J02161X/1 and EUFP7 ERC, Grant Agreement no. 336189 (TheraCav).
Glasgow Author(s) Enlighten ID:Prentice, Dr Paul
Authors: Fiabane, J., Prentice, P., and Pancholi, K.
College/School:College of Science and Engineering > School of Engineering > Systems Power and Energy
Journal Name:BioMed Research International
Publisher:Hindawi Publishing Corporation
ISSN (Online):2314-6141
Copyright Holders:Copyright © 2016 Joe Fiabane et al.
First Published:First published in BioMed Research International 2016: 3572827
Publisher Policy:Reproduced under a Creative Commons License

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