Gemmell, N. R., McCarthy, A., Kim, M. M., Veilleux, I., Zhu, T. C., Buller, G. S., Wilson, B. C. and Hadfield, R. H. (2017) A compact fiber-optic probe-based singlet oxygen luminescence detection system. Journal of Biophotonics, 10(2), pp. 320-326. (doi: 10.1002/jbio.201600078) (PMID:27455426) (PMCID:PMC5266677)
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Abstract
This paper presents a novel compact fiberoptic based singlet oxygen near-infrared luminescence probe coupled to an InGaAs/InP single photon avalanche diode (SPAD) detector. Patterned time gating of the single-photon detector is used to limit unwanted dark counts and eliminate the strong photosensitizer luminescence background. Singlet oxygen luminescence detection at 1270 nm is confirmed through spectral filtering and lifetime fitting for Rose Bengal in water, and Photofrin in methanol as model photosensitizers. The overall performance, measured by the signal-to-noise ratio, improves by a factor of 50 over a previous system that used a fiberoptic-coupled superconducting nanowire single-photon detector. The effect of adding light scattering to the photosensitizer is also examined as a first step towards applications in tissue in vivo.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Hadfield, Professor Robert and Gemmell, Mr Nathan |
| Authors: | Gemmell, N. R., McCarthy, A., Kim, M. M., Veilleux, I., Zhu, T. C., Buller, G. S., Wilson, B. C., and Hadfield, R. H. |
| College/School: | College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering |
| Journal Name: | Journal of Biophotonics |
| Publisher: | Wiley |
| ISSN: | 1864-063X |
| ISSN (Online): | 1864-0648 |
| Published Online: | 25 July 2016 |
| Copyright Holders: | Copyright © 2017 The Authors |
| First Published: | First published in Journal of Biophotonics 10(2): 320-326 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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