Ichim, G. and Tait, S. W.G. (2016) A fate worse than death: apoptosis as an oncogenic process. Nature Reviews Cancer, 16, pp. 539-548. (doi: 10.1038/nrc.2016.58) (PMID:27364482)
|
Text
120686.pdf - Accepted Version 7MB |
Abstract
Apoptotic cell death is widely considered a positive process that both prevents and treats cancer. Although undoubtedly having a beneficial role, paradoxically, apoptosis can also cause unwanted effects that may even promote cancer. In this Opinion article we highlight some of the ways by which apoptosis can exert oncogenic functions. We argue that fully understanding this dark side will be required to optimally engage apoptosis, thereby maximizing tumour cell kill while minimizing unwanted pro-tumorigenic effects.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Tait, Professor Stephen and Ichim, Dr Gabriel |
Authors: | Ichim, G., and Tait, S. W.G. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Nature Reviews Cancer |
Publisher: | Nature Publishing Group |
ISSN: | 1474-175X |
ISSN (Online): | 1474-1768 |
Published Online: | 01 July 2016 |
Copyright Holders: | Copyright © 2016 Macmillan Publishers |
First Published: | First published in Nature Reviews Cancer 16:539-548 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
University Staff: Request a correction | Enlighten Editors: Update this record