A fate worse than death: apoptosis as an oncogenic process

Ichim, G. and Tait, S. W.G. (2016) A fate worse than death: apoptosis as an oncogenic process. Nature Reviews Cancer, 16, pp. 539-548. (doi: 10.1038/nrc.2016.58) (PMID:27364482)

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Apoptotic cell death is widely considered a positive process that both prevents and treats cancer. Although undoubtedly having a beneficial role, paradoxically, apoptosis can also cause unwanted effects that may even promote cancer. In this Opinion article we highlight some of the ways by which apoptosis can exert oncogenic functions. We argue that fully understanding this dark side will be required to optimally engage apoptosis, thereby maximizing tumour cell kill while minimizing unwanted pro-tumorigenic effects.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Tait, Professor Stephen and Ichim, Dr Gabriel
Authors: Ichim, G., and Tait, S. W.G.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Nature Reviews Cancer
Publisher:Nature Publishing Group
ISSN (Online):1474-1768
Published Online:01 July 2016
Copyright Holders:Copyright © 2016 Macmillan Publishers
First Published:First published in Nature Reviews Cancer 16:539-548
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
690911Apoptosis as an oncogenic process: understanding and exploiting its dark-sideStephen TaitCancer Research UK (CAN-RES-UK)20145RI CANCER SCIENCES
607521A new approach to understanding mitochondrial functions in cell death, autophagy and beyondStephen TaitBiotechnology and Biological Sciences Research Council (BBSRC)BB/K008374/1RI CANCER SCIENCES
709841Targeting MCL-1 in breast cancerStephen TaitBreast Cancer Now (BCN)2015NovSPR589RI CANCER SCIENCES