Senescence can be BETter without the SASP?

Vizioli, M. G. and Adams, P. (2016) Senescence can be BETter without the SASP? Cancer Discovery, 6(6), pp. 576-578. (doi: 10.1158/ (PMID:27261480)

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Summary: Global remodeling of the chromatin landscape occurs during senescence, although its functional consequence is still unclear. In this issue, Tasdemir and colleagues show that the epigenetic regulator BRD4 is required for expression of the proinflammatory senescence-associated secretory phenotype and immune clearance of senescent cells in vitro and in vivo. Their results could be useful in the design of novel therapies to treat aging-related diseases, including cancer.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Vizioli, Dr Maria Grazia and Adams, Professor Peter
Authors: Vizioli, M. G., and Adams, P.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Cancer Discovery
Publisher:American Association for Cancer Research
ISSN (Online):2159-8290
Published Online:03 June 2016

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
510441Epigenetics of Aging and Age-associated diseases : Epigenetic regulation of senescence and agingPeter AdamsNational Institute of Health (USA) (NIH(US))P01 AG031862RI CANCER SCIENCES