Vizioli, M. G. and Adams, P. (2016) Senescence can be BETter without the SASP? Cancer Discovery, 6(6), pp. 576-578. (doi: 10.1158/2159-8290.cd-16-0485) (PMID:27261480)
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Abstract
Summary: Global remodeling of the chromatin landscape occurs during senescence, although its functional consequence is still unclear. In this issue, Tasdemir and colleagues show that the epigenetic regulator BRD4 is required for expression of the proinflammatory senescence-associated secretory phenotype and immune clearance of senescent cells in vitro and in vivo. Their results could be useful in the design of novel therapies to treat aging-related diseases, including cancer.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Vizioli, Dr Maria Grazia and Adams, Professor Peter |
| Authors: | Vizioli, M. G., and Adams, P. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Cancer Discovery |
| Publisher: | American Association for Cancer Research |
| ISSN: | 2159-8274 |
| ISSN (Online): | 2159-8290 |
| Published Online: | 03 June 2016 |
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