Dadonaite, B., Vijayakrishnan, S. , Fodor, E., Bhella, D. and Hutchinson, E. C. (2016) Filamentous influenza viruses. Journal of General Virology, 97(8), pp. 1755-1764. (doi: 10.1099/jgv.0.000535) (PMID:27365089)
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Abstract
Clinical isolates of influenza virus produce pleomorphic virus particles, including extremely long filamentous virions. In contrast, strains of influenza that have adapted to laboratory growth typically produce only spherical virions. As a result, the filamentous phenotype has been overlooked in most influenza virus research. Recent advances in imaging and improved animal models have highlighted the distinct structure and functional relevance of filamentous virions. In this review we summarise what is currently known about these strikingly elongated virus particles and discuss their possible roles in clinical infections.
| Item Type: | Articles |
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| Additional Information: | BD is funded by a Wellcome Trust studentship [105399/Z/14/Z]; EF is funded by an MRC programme grant [MR/K000241/1]; SV, DB and ECH are funded by core MRC funding to the MRC-University of Glasgow Centre for Virus Research and ECH is funded by an MRC Career Development Award [MR/N008618/1]. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Vijayakrishnan, Dr Swetha and Bhella, Professor David and Hutchinson, Dr Edward |
| Authors: | Dadonaite, B., Vijayakrishnan, S., Fodor, E., Bhella, D., and Hutchinson, E. C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
| Journal Name: | Journal of General Virology |
| Publisher: | Society for General Microbiology |
| ISSN: | 0022-1317 |
| ISSN (Online): | 1465-2099 |
| Published Online: | 30 June 2016 |
| Copyright Holders: | Copyright © 2016 The Authors |
| First Published: | First published in Journal of General Virology 97(8): 1755-1764 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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