Morton, C. A., Whitehurst, C., McColl, J. H. , Moore, J. V. and Mackie, R. M. (2001) Photodynamic therapy for large or multiple patches of Bowen disease and basal cell carcinoma. Archives of Dermatology, 137(3), pp. 319-324. (PMID:11255332)
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Publisher's URL: https://archderm.jamanetwork.com/article.aspx?articleid=478244
Abstract
Background: Photodynamic therapy (PDT) using topical δ-aminolevulinic acid (δ-ALA) is an effective treatment for Bowen disease and certain basal cell carcinomas (BCCs), but its place in clinical practice remains to be established. Patients with large and/or multiple lesions of Bowen disease or BCC can represent a considerable therapeutic challenge. We suggest that δ-ALA PDT may be of particular benefit in such patients. Observation: In an open study, 35 (88%) of 40 large patches of Bowen disease, all with a maximum diameter greater than 20 mm, cleared following 1 to 3 treatments of δ-ALA PDT, although 4 patches recurred within 12 months. δ-Aminolevulinic acid PDT was also used to treat 40 large BCCs, with an identical 88% initial clearance (after 1-3 treatments), with 4 recurrences within 34 months (range, 12-60 months). In 10 further patients with multiple (≥3) patches of Bowen disease, 44 (98%) of 45 patches cleared following δ-ALA PDT, although 4 lesions recurred over 12 months. In 3 patients with multiple BCCs, PDT cleared 52 (90%) of 58 lesions, with 2 recurrences during 41 months (range, 12-52 months). Treatments were well tolerated, with only 5 patients with solitary large lesions requiring local anesthesia. Conclusions: δ-Aminolevulinic acid PDT is an effective tissue-sparing modality achieving good cosmesis. We propose that δ-ALA PDT be considered as a first-line therapy for large and/or multiple areas of Bowen disease and superficial BCCs.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Mackie, Professor Rona and McColl, Professor John and Morton, Dr Colin |
| Authors: | Morton, C. A., Whitehurst, C., McColl, J. H., Moore, J. V., and Mackie, R. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing College of Science and Engineering > School of Mathematics and Statistics > Statistics |
| Journal Name: | Archives of Dermatology |
| Journal Abbr.: | Arch Dermatol. |
| Publisher: | American Medical Association |
| ISSN: | 0003-987X |
| ISSN (Online): | 1538-3652 |
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