de Souza, W. M., Acrani, G. O., Romeiro, M. F., Reis Jr., O., Tolardo, A. L., da Silva, S. P., de Almeida Medeiros, D. B., Varela, M., Nunes, M. R. T. and Figueiredo, L. T. M. (2016) Molecular characterization of Capim and Enseada orthobunyaviruses. Infection, Genetics and Evolution, 40, pp. 47-53. (doi: 10.1016/j.meegid.2016.02.024) (PMID:26921797)
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Abstract
Capim and Enseada viruses are members of the genus Orthobunyavirus isolated from mosquitoes and mammals in Brazil. Despite seroprevalence studies indicating human infections in Latin America, these viruses remain relatively unknown and unstudied. In order to better understand the genetic and evolutionary relationships among orthobunyaviruses, we sequenced the three genomic segments of Capim and Enseada orthobunyaviruses. Based on phylogenetic analysis, we demonstrated that these viruses depicted two new distinct clades, one represented by Enseada and another composed of Capim virus. In general, the genome organization and genetic traits of these viruses are similar to other orthobunyaviruses however, the open reading frame (ORF) of the putative nonstructural NSs protein of Enseada orthobunyavirus precedes the nucleocapsid ORF. Overall, our study provides details on the molecular characteristics of the prototype species of two groups within the Orthobunyavirus genus, revealing novel features into the genetic diversity and evolution of this genus.
| Item Type: | Articles |
|---|---|
| Additional Information: | This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil (Grant Nos. 13/14929-1 and 14/02438-6, and Scholarship Nos. 12/24150-9, 15/05778-5 and 14/20851-8). MRTN is supported by the CNPq (Grant Nos 302032/2011-8 and 200024/2015-9). LTM. Figueiredo is recipient of a CNPq 1B senior fellowship (No. 301677/2013-1). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Varela, Dr Mariana |
| Authors: | de Souza, W. M., Acrani, G. O., Romeiro, M. F., Reis Jr., O., Tolardo, A. L., da Silva, S. P., de Almeida Medeiros, D. B., Varela, M., Nunes, M. R. T., and Figueiredo, L. T. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Infection, Genetics and Evolution |
| Publisher: | Elsevier |
| ISSN: | 1567-1348 |
| Published Online: | 26 February 2016 |
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