Definition of myocardial tissue abnormalities in end stage renal failure with cardiac magnetic resonance imaging using T1 mapping

Rutherford, E. et al. (2016) Definition of myocardial tissue abnormalities in end stage renal failure with cardiac magnetic resonance imaging using T1 mapping. Kidney International, 90(4), pp. 845-852. (doi: 10.1016/j.kint.2016.06.014)

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Noninvasive quantification of myocardial fibrosis in end-stage renal disease is challenging. Gadolinium contrast agents previously used for cardiac magnetic resonance imaging (MRI) are contraindicated because of an association with nephrogenic systemic fibrosis. In other populations, increased myocardial native T1 times on cardiac MRI have been shown to be a surrogate marker of myocardial fibrosis. We applied this method to 33 incident hemodialysis patients and 28 age- and sex-matched healthy volunteers who underwent MRI at 3.0T. Native T1 relaxation times and feature tracking–derived global longitudinal strain as potential markers of fibrosis were compared and associated with cardiac biomarkers. Left ventricular mass indices were higher in the hemodialysis than the control group. Global, Septal and midseptal T1 times were all significantly higher in the hemodialysis group (global T1 hemodialysis 1171 ± 27 ms vs. 1154 ± 32 ms; septal T1 hemodialysis 1184 ± 29 ms vs. 1163 ± 30 ms; and midseptal T1 hemodialysis 1184 ± 34 ms vs. 1161 ± 29 ms). In the hemodialysis group, T1 times correlated with left ventricular mass indices. Septal T1 times correlated with troponin and electrocardiogram-corrected QT interval. The peak global longitudinal strain was significantly reduced in the hemodialysis group (hemodialysis -17.7±5.3% vs. -21.8±6.2%). For hemodialysis patients, the peak global longitudinal strain significantly correlated with left ventricular mass indices (R = 0.426), and a trend was seen for correlation with galectin-3, a biomarker of cardiac fibrosis. Thus, cardiac tissue properties of hemodialysis patients consistent with myocardial fibrosis can be determined noninvasively and associated with multiple structural and functional abnormalities.

Item Type:Articles
Additional Information:We acknowledged British Heart Foundation (FS/15/5431639) training fellowship to Dr Kenneth Mangion (co author) and grant Kidney Research UK (IN02/2013).
Glasgow Author(s) Enlighten ID:Patel, Dr Rajan and Mccomb, Dr Christie and Rauhalammi, Mr Samuli and Mangion, Dr Kenneth and Rutherford, Dr Elaine and Woodward, Miss Rosemary and Roditi, Dr Giles and Mark, Professor Patrick and Welsh, Professor Paul and Berry, Professor Colin and Jardine, Professor Alan and Radjenovic, Dr Aleksandra
Authors: Rutherford, E., Talle, M. A., Mangion, K., Bell, E., Rauhalammi, S. M., Roditi, G., McComb, C., Radjenovic, A., Welsh, P., Woodward, R., Struthers, A. D., Jardine, A. G., Patel, R. K., Berry, C., and Mark, P. B.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Kidney International
ISSN (Online):1523-1755
Published Online:05 August 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Kidney International 90(4):845-852
Publisher Policy:Reproduced under a Creative Commons License
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