Holzer, B., Hodgson, S., Logan, N., Willett, B. and Baron, M. D. (2016) Protection of cattle against rinderpest by vaccination with wild-type but not attenuated strains of peste des petits ruminants virus. Journal of Virology, 90(10), pp. 5152-5162. (doi: 10.1128/jvi.00040-16) (PMID:26984722) (PMCID:PMC4859729)
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Abstract
Although rinderpest virus (RPV) has been eradicated in the wild, efforts are still continuing to restrict the extent to which live virus is distributed in facilities around the world and to prepare for any reappearance of the disease, whether through deliberate or accidental release. In an effort to find an alternative vaccine which could be used in place of the traditional live attenuated RPV strains, we have determined whether cattle can be protected from rinderpest by inoculation with vaccine strains of the related morbillivirus, peste des petits ruminants virus (PPRV). Cattle were vaccinated with wild-type PPRV or either of two established PPRV vaccine strains, Nigeria/75/1 or Sungri/96. All animals developed antibody and T cell immune responses to the inoculated PPRV. However, only the animals given wild-type PPRV were protected from RPV challenge. Animals given PPRV/Sungri/96 were only partially protected, and animals given PPRV/Nigeria/75/1 showed no protection against RPV challenge. While sera from animals vaccinated with the vaccine strain of RPV showed cross-neutralizing ability against PPRV, none of the sera from animals vaccinated with any strain of PPRV was able to neutralize RPV although sera from animals inoculated with wild-type PPRV were able to neutralize RPV-pseudotyped vesicular stomatitis virus.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Baron, Dr Michael and Willett, Professor Brian and Logan, Miss Nicola |
Authors: | Holzer, B., Hodgson, S., Logan, N., Willett, B., and Baron, M. D. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus Research |
Journal Name: | Journal of Virology |
Publisher: | American Society for Microbiology |
ISSN: | 0022-538X |
ISSN (Online): | 1098-5514 |
Published Online: | 16 March 2016 |
Copyright Holders: | Copyright © 2016 Holzer et al. |
First Published: | First published in Journal of Virology 90(10): 5152-5162 |
Publisher Policy: | Reproduced under a Creative Commons License |
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