Associations between weight change and biomarkers of cardiometabolic risk in South Asians: secondary analyses of the PODOSA Trial

Welsh, P. et al. (2016) Associations between weight change and biomarkers of cardiometabolic risk in South Asians: secondary analyses of the PODOSA Trial. International Journal of Obesity, 40(6), pp. 1005-1011. (doi: 10.1038/ijo.2016.35) (PMID:26927315) (PMCID:PMC4892347)

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Background/Objectives: The association of weight changes with cardiometabolic biomarkers in South Asians has been sparsely studied. Subjects/Methods: We measured cardiometabolic biomarkers at baseline and after 3 years in the Prevention of Diabetes and Obesity in South Asians Trial. We investigated the effect of a lifestyle intervention on biomarkers in the randomized groups. In addition, treating the population as a single cohort, we estimated the association between change in weight and change in biomarkers. Results: Complete data were available at baseline and after 3 years in 151 participants. At 3 years, there was an adjusted mean reduction of 1·44 kg (95% confidence interval (95% CI): 0.18–2.71) in weight and 1.59 cm (95% CI: 0.08–3.09) in waist circumference in the intervention arm as compared with the control arm. There was no clear evidence of difference between the intervention and control arms in change of mean value of any biomarker. As a single cohort, every 1 kg weight reduction during follow-up was associated with a reduction in triglycerides (−1.3%, P=0.048), alanine aminotransferase (−2.5%, P=0.032), gamma-glutamyl transferase (−2.2%, P=0.040), leptin (−6.5%, P<0.0001), insulin (−3.7%, P=0.0005), fasting glucose (−0.8%, P=0.0071), 2-h glucose (−2.3%, P=0.0002) and Homeostatic Model Assessment of insulin resistance (HOMA-IR: −4.5%, P=0.0002). There was no evidence of associations with other lipid measures, tissue plasminogen activator, markers of inflammation or blood pressure. Conclusions: We demonstrate that modest weight decrease in SAs is associated with improvements in markers of total and ectopic fat as well as insulin resistance and glycaemia in South Asians at risk of diabetes. Future trials with more intensive weight change are needed to extend these findings.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Lean, Professor Michael and Gill, Professor Jason and Welsh, Professor Paul and Sattar, Professor Naveed
Authors: Welsh, P., Cezard, G., Gill, J.M., Wallia, S., Douglas, A., Sheikh, A., Wild, S.H., Tuomilehto, J., McKnight, J., Murray, G., Bhopal, R., Lean, M., and Sattar, N.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:International Journal of Obesity
Publisher:Nature Publishing Group
ISSN (Online):1476-5497
Published Online:22 March 2016
Copyright Holders:Copyright © 2016 Nature Publishing Group
First Published:First published in International Journal of Obesity 40(6): 1005-1011
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
612031Cardiac biomarkers and CVD risk screening: a cost-effective public health measure?Paul WelshBritish Heart Foundation (BHF)FS/12/62/29889RI CARDIOVASCULAR & MEDICAL SCIENCES