Respiratory challenge MRI: practical aspects

Moreton, F. C., Dani, K. A., Goutcher, C., O'Hare, K. and Muir, K. W. (2016) Respiratory challenge MRI: practical aspects. NeuroImage: Clinical, 11, pp. 667-677. (doi: 10.1016/j.nicl.2016.05.003)

118958.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.



Respiratory challenge MRI is the modification of arterial oxygen (PaO2) and/or carbon dioxide (PaCO2) concentration to induce a change in cerebral function or metabolism which is then measured by MRI. Alterations in arterial gas concentrations can lead to profound changes in cerebral haemodynamics which can be studied using a variety of MRI sequences. Whilst such experiments may provide a wealth of information, conducting them can be complex and challenging. In this paper we review the rationale for respiratory challenge MRI including the effects of oxygen and carbon dioxide on the cerebral circulation. We also discuss the planning, equipment, monitoring and techniques that have been used to undertake these experiments. We finally propose some recommendations in this evolving area for conducting these experiments to enhance data quality and comparison between techniques.

Item Type:Articles
Glasgow Author(s) Enlighten ID:O'Hare, Dr Kevin and Moreton, Dr Fiona and Muir, Professor Keith and Dani, Dr Krishna
Authors: Moreton, F. C., Dani, K. A., Goutcher, C., O'Hare, K., and Muir, K. W.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:NeuroImage: Clinical
Published Online:06 May 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in NeuroImage: Clinical 11:667-677
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
606561Cerebral and peripheral perfusion and reactivity in CADASIL: a longitudinal pilot studyKeith MuirScottish Executive Health Department (SEHHD-CSO)ETM/244INP - STROKE & BRAIN IMAGING
549781Metabolic MRI in Acute Stroke; Development and Validation of the 'Oxygen Challenge' TechniqueKeith MuirScottish Executive Health Department (SEHHD-CSO)ETM/104RI NEUROSCIENCE & PSYCHOLOGY