Circulating markers of ageing and allostatic load: a slow train coming

Shiels, P. G. , Stenvinkel, P., Kooman, J. P. and McGuinness, D. (2017) Circulating markers of ageing and allostatic load: a slow train coming. Practical Laboratory Medicine, 7, pp. 49-54. (doi: 10.1016/j.plabm.2016.04.002) (PMID:28856219) (PMCID:PMC5574864)

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Dealing with the growing burden of age-related morbidities is one of the greatest challenges facing modern society. How we age across the lifecourse and how psychosocial and lifestyle factors interplay with the biology of ageing remains to be fully elucidated. Sensitive and specific biomarkers with which to interrogate the biology of the ageing process are sparse. Recent evidence suggests that non-coding RNAs are key determinants of such processes and that these can be used as potential circulatory bio-markers of ageing. They may also provide a mechanism which mediates the spread of allostatic load across the body over time, ultimately reflecting the immunological health and physiological status of tissues and organs. The interplay between exosomal microRNAs and ageing processes is still relatively unexplored, although circulating microRNAs have been linked to the regulation of a range of physiological and pathological processes and offer insight into mechanistic determinants of healthspan.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Shiels, Professor Paul and McGuinness, Dr Dagmara
Authors: Shiels, P. G., Stenvinkel, P., Kooman, J. P., and McGuinness, D.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Practical Laboratory Medicine
Published Online:19 April 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Practical Laboratory Medicine 7:49-54
Publisher Policy:Reproduced under a Creative Commons License

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