CD4+ T-cell survival in the GI tract requires dectin-1 during fungal infection

Drummond, R.A., Dambuza, I.M., Vautier, S., Taylor, J.A., Reid, D.M., Bain, C.C., Underhill, D.M., Masopust, D., Kaplan, D.H. and Brown, G.D. (2016) CD4+ T-cell survival in the GI tract requires dectin-1 during fungal infection. Mucosal Immunology, 9(2), pp. 492-502. (doi: 10.1038/mi.2015.79) (PMID:26349660) (PMCID:PMC4677461)

Abstract

Dectin-1 is an innate antifungal C-type lectin receptor necessary for protective antifungal immunity. We recently discovered that Dectin-1 is involved in controlling fungal infections of the gastrointestinal (GI) tract, but how this C-type lectin receptor mediates these activities is unknown. Here, we show that Dectin-1 is essential for driving fungal-specific CD4+ T-cell responses in the GI tract. Loss of Dectin-1 resulted in abrogated dendritic cell responses in the mesenteric lymph nodes (mLNs) and defective T-cell co-stimulation, causing substantial increases in CD4+ T-cell apoptosis and reductions in the cellularity of GI-associated lymphoid tissues. CD8+ T-cell responses were unaffected by Dectin-1 deficiency. These functions of Dectin-1 have significant implications for our understanding of intestinal immunity and susceptibility to fungal infections.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Bain, Mr Calum
• Authors: Drummond, R.A., Dambuza, I.M., Vautier, S., Taylor, J.A., Reid, D.M., Bain, C.C., Underhill, D.M., Masopust, D., Kaplan, D.H., and Brown, G.D.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Mucosal Immunology
• Publisher: Nature Publishing Group
• ISSN: 1933-0219
• ISSN (Online): 1935-3456
• Published Online: 09 September 2015
• Copyright Holders: Copyright © 2016 Society for Mucosal Immunology
• First Published: First published in Mucosal Immunology 9(2):492-502
• Publisher Policy: Reproduced under a Creative Commons License