Rutherford, E., Weir-McCall, J. R., Patel, R. K., Houston, J. G., Roditi, G., Struthers, A. D., Jardine, A. G. and Mark, P. B. (2017) Research cardiac magnetic resonance imaging in end stage renal disease - incidence, significance and implications of unexpected incidental findings. European Radiology, 27(1), pp. 315-324. (doi: 10.1007/s00330-016-4288-4) (PMID:27053260)
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Abstract
Objectives: Left ventricular mass (LVM) at cardiac magnetic resonance imaging (CMR) is a frequent end point in clinical trials in nephrology. Trial participants with end stage renal disease (ESRD) may have a greater frequency of incidental findings (IF). We retrospectively investigated prevalence of IF in previous research CMR and reviewed their subsequent impact on participants. Methods: Between 2002 and 2006, 161 ESRD patients underwent CMR in a transplant assessment study. Images were used to assess LV mass and function. In the current study a radiologist reviewed the scans for IF. Review of patient records determined the subsequent clinical significance of IF. Results: There were 150 IF in 95 study participants. Eighty-four (56 %) were new diagnoses. One hundred and two were non-cardiac. Fifteen were suspicious of malignancy. There was a clinically significant IF for 14.9 % of the participants. In six cases earlier identification of an IF may have improved quality of life or survival. Conclusions: Without radiology support clinically important IF may be missed on CMR. Patients undergoing CMR in trials should be counselled about the frequency and implications of IF. Patients with ESRD have a higher prevalence of IF than reported in other populations. Nephrology studies require mechanisms for radiologist reporting and strategies for dealing with IF.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Patel, Dr Rajan and Rutherford, Dr Elaine and Roditi, Dr Giles and Mark, Professor Patrick and Jardine, Professor Alan |
Authors: | Rutherford, E., Weir-McCall, J. R., Patel, R. K., Houston, J. G., Roditi, G., Struthers, A. D., Jardine, A. G., and Mark, P. B. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
Journal Name: | European Radiology |
Publisher: | Springer Berlin Heidelberg |
ISSN: | 0938-7994 |
ISSN (Online): | 1432-1084 |
Published Online: | 07 April 2016 |
Copyright Holders: | Copyright © 2016 The Authors |
First Published: | First published in European Radiology 27(1): 315-324 |
Publisher Policy: | Reproduced under a Creative Commons License |
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