Holmes, M. A., Harrison, E. M., Fisher, E. A., Graham, E. M., Parkhill, J., Foster, G. and Paterson, G. K. (2016) Genomic analysis of companion rabbit staphylococcus aureus. PLoS ONE, 11(3), e0151458. (doi: 10.1371/journal.pone.0151458) (PMID:26963381) (PMCID:PMC4786088)
|
Other
18342.PDF - Published Version Available under License Creative Commons Attribution. 246kB |
Abstract
In addition to being an important human pathogen, Staphylococcus aureus is able to cause a variety of infections in numerous other host species. While the S. aureus strains causing infection in several of these hosts have been well characterised, this is not the case for companion rabbits (Oryctolagus cuniculus), where little data are available on S. aureus strains from this host. To address this deficiency we have performed antimicrobial susceptibility testing and genome sequencing on a collection of S. aureus isolates from companion rabbits. The findings show a diverse S. aureus population is able to cause infection in this host, and while antimicrobial resistance was uncommon, the isolates possess a range of known and putative virulence factors consistent with a diverse clinical presentation in companion rabbits including severe abscesses. We additionally show that companion rabbit isolates carry polymorphisms within dltB as described as underlying host-adaption of S. aureus to farmed rabbits. The availability of S. aureus genome sequences from companion rabbits provides an important aid to understanding the pathogenesis of disease in this host and in the clinical management and surveillance of these infections.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Graham, Dr Libby |
| Authors: | Holmes, M. A., Harrison, E. M., Fisher, E. A., Graham, E. M., Parkhill, J., Foster, G., and Paterson, G. K. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | PLoS ONE |
| Publisher: | Public Library of Science |
| ISSN: | 1932-6203 |
| ISSN (Online): | 1932-6203 |
| Published Online: | 10 March 2016 |
| Copyright Holders: | Copyright © 2016 Holmes et al. |
| First Published: | First published in PLoS ONE 11(3):e0151458 |
| Publisher Policy: | Reproduced under a Creative Commons License |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
Deposit and Record Details