Immune effector mechanism in parasitic infections

Liew, F.Y., Xu, D. and Ling Chan, W. (1999) Immune effector mechanism in parasitic infections. Immunology Letters, 65(1-2), pp. 101-104. (doi: 10.1016/S0165-2478(98)00131-X) (PMID:10065634)

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In this article is a summary of our recent findings on the role of nitric oxide (NO) as an effector mechanism against the intracellular parasite, Leishmania major. NO is produced in large amounts in murine macrophages following activation by IFNγ synthesized by Th1 cells. NO production is inhibited by IL-4, a product of Th2 cells. A set of stable cell surface markers has now been identified. ST2L and IL-18R are selectively expressed on Th2 and Th1 cells respectively. Antibody against ST2L can down-regulate Th2 cells in the highly susceptible BALB/c mice leading to control of otherwise fatal L. major infection. These results show directly the critical role of the balance between Th1 and Th2 cells in cutaneous leishmaniasis.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Liew, Prof Foo and Xu, Dr Damo
Authors: Liew, F.Y., Xu, D., and Ling Chan, W.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Immunology Letters
ISSN (Online):1879-0542

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