The multifaceted role of astrocytes in regulating myelination

Kiray, H., Lindsay, S. L. , Hosseinzadeh, S. and Barnett, S. C. (2016) The multifaceted role of astrocytes in regulating myelination. Experimental Neurology, 283(Pt. B), pp. 541-549. (doi: 10.1016/j.expneurol.2016.03.009) (PMID:26988764) (PMCID:PMC5019113)

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Astrocytes are the major glial cell of the central nervous system (CNS), providing both metabolic and physical support to other neural cells. After injury, astrocytes become reactive and express a continuum of phenotypes which may be supportive or inhibitory to CNS repair. This review will focus on the ability of astrocytes to influence myelination in the context of specific secreted factors, cytokines and other neural cell targets within the CNS. In particular, we focus on how astrocytes provide energy and cholesterol to neurons, influence synaptogenesis, affect oligodendrocyte biology and instigate cross-talk between the many cellular components of the CNS.

Item Type:Articles
Additional Information:This work was funded by The Wellcome Trust (HK, WT083434), Medical Research Council (SL, MR/J004731/1) and Medical Research Scotland (SH, PhD-718- 2013).# I have the invoice of 2142.10 E,
Glasgow Author(s) Enlighten ID:Barnett, Professor Susan and Lindsay, Dr Susan
Authors: Kiray, H., Lindsay, S. L., Hosseinzadeh, S., and Barnett, S. C.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Experimental Neurology
Journal Abbr.:Exp Neurol
ISSN (Online):1090-2430
Published Online:14 March 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in Experimental Neurology 283(Pt. B):541-549
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
584331Does cellular niche affect the repair potential of mesenchymal stem cells; implications for spinal cord injury?Susan BarnettMedical Research Council (MRC)MR/J004731/1III -IMMUNOLOGY
664461Development of polymer scaffolds for use in the repair of spinal cord injurySusan BarnettMedical Research Scotland (MED-SCOT)PhD-718-2013III -IMMUNOLOGY
576663Identification of astrocytic factors that regulate myelinationSusan BarnettWellcome Trust (WELLCOME)WT089891MAIII -IMMUNOLOGY