Kiray, H., Lindsay, S. L. , Hosseinzadeh, S. and Barnett, S. C. (2016) The multifaceted role of astrocytes in regulating myelination. Experimental Neurology, 283(Pt. B), pp. 541-549. (doi: 10.1016/j.expneurol.2016.03.009) (PMID:26988764) (PMCID:PMC5019113)
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Abstract
Astrocytes are the major glial cell of the central nervous system (CNS), providing both metabolic and physical support to other neural cells. After injury, astrocytes become reactive and express a continuum of phenotypes which may be supportive or inhibitory to CNS repair. This review will focus on the ability of astrocytes to influence myelination in the context of specific secreted factors, cytokines and other neural cell targets within the CNS. In particular, we focus on how astrocytes provide energy and cholesterol to neurons, influence synaptogenesis, affect oligodendrocyte biology and instigate cross-talk between the many cellular components of the CNS.
| Item Type: | Articles |
|---|---|
| Additional Information: | This work was funded by The Wellcome Trust (HK, WT083434), Medical Research Council (SL, MR/J004731/1) and Medical Research Scotland (SH, PhD-718- 2013).# I have the invoice of 2142.10 E, |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Barnett, Professor Susan and Lindsay, Dr Susan |
| Authors: | Kiray, H., Lindsay, S. L., Hosseinzadeh, S., and Barnett, S. C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Experimental Neurology |
| Journal Abbr.: | Exp Neurol |
| Publisher: | Elsevier |
| ISSN: | 0014-4886 |
| ISSN (Online): | 1090-2430 |
| Published Online: | 14 March 2016 |
| Copyright Holders: | Copyright © 2016 The Authors |
| First Published: | First published in Experimental Neurology 283(Pt. B):541-549 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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