Lyall, D. M. et al. (2015) APOE/TOMM40genetic loci, white matter hyperintensities, and cerebral microbleeds. International Journal of Stroke, 10(8), pp. 1297-1300. (doi: 10.1111/ijs.12615) (PMID:26310205)
|
Text
117969.pdf - Published Version Available under License Creative Commons Attribution. 110kB |
Abstract
Background: Two markers of cerebral small vessel disease are white matter hyperintensities and cerebral microbleeds, which commonly occur in people with Alzheimer's disease. Aim and/or hypothesis: To test for independent associations between two Alzheimer's disease-susceptibility gene loci – APOE ε and the TOMM40 ‘523’ poly-T repeat – and white matter hyperintensities/cerebral microbleed burden in community-dwelling older adults. Methods: Participants in the Lothian Birth Cohort 1936 underwent genotyping for APOE ε and TOMM40 523, and detailed structural brain magnetic resonance imaging at a mean age of 72·70 years (standard deviation = 0·7; range = 71–74). Results: No significant effects of APOE ε or TOMM40 523 genotypes on white matter hyperintensities or cerebral microbleed burden were found amongst 624 participants. Conclusions: Lack of association between two Alzheimer's disease susceptibility gene loci and markers of cerebral small vessel disease may reflect the relative health of this population compared with those in other studies in the literature.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Lyall, Dr Donald |
| Authors: | Lyall, D. M., Muñoz Maniega, S., Harris, S. E., Bastin, M. E., Murray, C., Lutz, M. W., Saunders, A. M., Roses, A. D., Valdés Hernández, M. d. C., Royle, N. A., Starr, J. M., Porteous, D. J., Deary, I. J., and Wardlaw, J. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health |
| Journal Name: | International Journal of Stroke |
| Publisher: | Wiley |
| ISSN: | 1747-4930 |
| ISSN (Online): | 1747-4949 |
| Copyright Holders: | Copyright © 2015 The Authors |
| First Published: | First published in International Journal of Stroke 10(8):1297-1300 |
| Publisher Policy: | Reproduced under a Creative Commons License |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
Deposit and Record Details